Objective: To study the improvement of Chaishao Jieyu decoction combined with Pingxiao capsule on the mental state、immune function and endometrium of patients with luminal breast cancer undergoing endocrine therapy after operation. Methods: 60 cases of luminal breast cancer patients after operation, according to the method of random grouping would be divided into the control group and the observation group,each group 30 cases.The control group were treated with tamoxifen. On the basis,the observation group accepted oral administration of Chaishao Jieyu Decoction and Pingxiao capsule . The levels of 5-HT、DA、T lymphocyte subsets 、IGF-1 and endometrial thickness were compared. Results: At the end of treatment,the observation group's 5-HT、DA、CD3+、CD4+levels were obviously higher than the control group(P<0.05),the observation group's CD8+levels、IGF-1 levels and endometrial thickness were significantly lower than the control group(P<0.05). Conclusion: Chaishao Jieyu Decoction combined with Pingxiao capsule can significantly improve the mental state、immune function of patients with luminal breast cancer undergoing endocrine therapy after surgery,and inhibit their endometrial thickening,the effect is exact.