电离辐射、细胞因子等物理和化学因素引起的ＮＦκＢ 的激活，是细胞的一种应激反应，它能对细胞提供有益的保护，增加其应激耐受性。ＮＦκＢ 的保护机制与它激活的应激反应类“即刻基因”的转录表达有关，亦可能与ＮＦκＢ 能使一些保护蛋白基因的转录上调有关。通过ＩκＢα的基因治疗或应用如蛋白酶抑制剂一类的ＮＦκＢ 功能封阻剂，来抑制ＮＦκＢ 活性，可增加细胞对电离辐射、ＴＮＦ 作用的敏感性，因而可提高传统的抗肿瘤、抗炎症、感染类治疗方法的疗效 Activation of NF-kappa B by physical and chemical factors such as ionizing radiation and cytokines is a stress response of cells, which can provide beneficial protection to cells and increase their stress tolerance. The protective mechanism of NF-kappaB is related to the transcriptional expression of the “immediate gene” in the stress response it activates, and it may also be related to the upregulation of some protective protein genes by NF-kappaB. The gene therapy of IκBα or application of NF-κB functional blockers such as protease inhibitors to inhibit NF κB activity can increase the sensitivity of cells to ionizing radiation and TNF, and thus can increase the traditional anti-tumor, Anti-inflammatory and infectious treatment