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目的观察DF方案化疗合并放射治疗老年中晚期食管癌的疗效及其毒副反应。方法将50例老年中晚期食管癌患者随机配对分为两组行前瞻性临床研究。一组25例放射治疗开始行DF方案化疗(综合组),另一组25例行单纯放疗(单放组)。放射治疗均采用6 MV X线常规分割外照射,靶区剂量为50~60 Gy。结果综合组和单放组放疗半量时有效率(CR+PR)分别为68.0%和36.0%(P<0.05);放疗全量时有效率分别为88.0%和64.0%(P<0.05)。综合组食管炎发生率为48.0%,单放组为24.0%(P<0.05)。综合组52.0%患者出现白细胞减少,单放组20.0%患者出现白细胞减少(P<0.05)。其他毒副反应差异无显著性。结论DF方案化疗合并放射治疗能显著提高老年中晚期食管癌患者的局控率,近期疗效显著。毒副反应明显加重,但经过积极治疗,患者可以耐受。
Objective To observe the curative effect and toxicity of DF regimen combined with radiotherapy on advanced esophageal cancer in elderly patients. Methods 50 elderly patients with advanced esophageal cancer were randomly paired into two groups prospective clinical study. A group of 25 patients underwent radiotherapy DF regimen chemotherapy (combined group), another group of 25 patients underwent radiotherapy alone (radiotherapy group). Radiation therapy using 6 MV X-ray conventional external beam irradiation, the target dose of 50 ~ 60 Gy. Results The effective rate (CR + PR) was 68.0% and 36.0% respectively in the combination group and the radiotherapy alone group (P <0.05). The total effective rate of radiotherapy was 88.0% and 64.0% respectively (P <0.05). The incidence of esophagitis in the combined group was 48.0% and that in the single group was 24.0% (P <0.05). Leukopenia occurred in 52.0% of patients in combination group and leukopenia in 20.0% of patients in combined group (P <0.05). No significant differences in other side effects. Conclusion DF regimen chemotherapy combined with radiotherapy can significantly improve the elderly patients with advanced esophageal cancer control rate, the recent significant effect. Toxic side effects significantly increased, but after active treatment, patients can tolerate.