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目的了解口服重组 B 亚单位/菌体霍乱菌苗(肠溶胶囊)在服用后的不良反应,为其推广应用提供科学依据。方法选择天津国际旅行卫生保健中心体检并进行霍乱预防接种人员798人,全程口服重组 B 亚单位/菌体霍乱菌苗,观察服药后的副作用。结果没有严重副作用发生,服药后的副作用均为一过性的腹痛、腹泻、头晕等,总副作用发生率为0.75%。结论口服重组 B 亚单位/菌体霍乱菌苗副作用发生率低,无严重副反应发生,可以考虑在适当人群中推广应用。
Objective To understand the adverse reactions of oral recombinant B subunit / bacterial cholera vaccine (enteric-coated capsules) after administration, and provide a scientific basis for its application. Methods A total of 798 HIV-infected cholera vaccines were obtained from the Tianjin International Travel Health Care Center. Oral recombinant B subunit / mycobacterium cholerae vaccine were administered orally to observe the side effects after taking the drug. The results no serious side effects, medication side effects are transient abdominal pain, diarrhea, dizziness, etc., the total incidence of side effects was 0.75%. Conclusions The incidence of side effects of oral recombinant B subunit / bacterial cholera vaccine is low, no serious side effects occur, which can be considered in the appropriate population to promote the application.