外阴阴道假丝酵母菌病(vulvovaginal candidia-sis,VVC)主要由白假丝酵母菌(Candida albicans)引起~[1],光滑假丝酵母菌(Candida glabrata)是非白假丝酵母菌的主要致病菌~[2]。对于该类妇科感染性疾病,临床上可用的抗真菌药物,在不正确的使用下,常常引起真菌对其耐药,使得VVC的治疗变得棘手。而假丝酵母菌的主要耐药机制有:药物的靶位发生变化、增强外排以及减少抗真菌药物的 Vulvovaginal candidiasis (VVC) is mainly caused by Candida albicans ~ [1], Candida glabrata is the major cause of non-Candida albicans Bacteria ~ [2]. For such gynecological infectious diseases, clinically useful antifungal drugs, which are often incorrectly inactivated by the fungus, render the treatment of VVC difficult. The main mechanisms of Candida resistance are: drug target changes, enhance efflux and reduce the anti-fungal drug