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目的:观察血清脑利钠肽前体(proBNP)水平的变化在心功能衰竭中的临床应用价值。方法:采用电化学发光法测定45例心衰患者、30例健康成人(对照组)血清proBNPⅡ水平,比较proBNPⅡ水平的变化。结果:心衰组血清proBNPⅡ水平(1593.4±537.8pg/ml)显著高于对照组(104.2±67.3pg/ml),有统计学意义(P<0.01),经临床治疗后血清proBNPⅡ水平(347.6±185.2)明显下降。结论:血清proBNP水平对于心力衰竭的诊断、治疗和预后评估具有重要的临床意义。
Objective: To observe the clinical value of changes of serum brain natriuretic peptide (proBNP) level in heart failure. Methods: The levels of proBNPⅡ in 45 patients with heart failure and 30 healthy adults (control group) were measured by electrochemiluminescence method and the levels of proBNPⅡ were compared. Results: The level of serum proBNPⅡin the heart failure group (1593.4 ± 537.8pg / ml) was significantly higher than that in the control group (104.2 ± 67.3pg / ml), with statistical significance (P <0.01) 185.2) decreased significantly. Conclusion: Serum proBNP level has important clinical significance for the diagnosis, treatment and prognosis of heart failure.