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随着配型技术及新型免疫抑制剂的临床应用,器官或组织移植术后早期急性免疫排斥反应发生率明显下降,慢性移植物失功则成为导致远期移植失败的主要原因之一。研究表明角膜移植术后和全身器官移植术后同样存在角膜植片慢性失功的过程,且角膜植片慢性失功已经成为再次角膜移植的主要原因之一。因此,重视角膜植片慢性失功对其临床防治及延长角膜植片的存活率有着重要的意义。
With the clinical application of matching technology and new immunosuppressive agents, the incidence of acute rejection after organ or tissue transplantation is significantly decreased, and chronic graft loss becomes one of the major causes of long-term graft failure. Studies have shown that after corneal transplantation and systemic organ transplantation there is also the process of chronic failure of corneal graft, and corneal graft chronic failure has become one of the main reasons for re-corneal transplantation. Therefore, attention to chronic failure of corneal graft for its clinical prevention and treatment of corneal graft to extend the survival rate is of great significance.