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子痫前期(pre-eclamptic,PE)病因至今尚未阐明。基因异常表达及其多态性在子痫前期的发病中起重要作用。DNA微阵技术、DNA探针技术的运用发现了一部分与子痫前期有关的遗传基因,例如:人类白细胞抗原、内皮型一氧化氮合酶、血管内皮生长因子、血管紧张素转化酶、血管紧张素II受体等基因的变异及多态性,具备这些基因的患者其子痫前期的发病率明显增加,基因的改变影响相应系统功能发生障碍,最终导致子痫前期发生。随着分子生物学技术的发展,必将发现易患基因,使子痫前期的早期筛查和早期诊断有可能实现。
The cause of pre-eclamptic (PE) has not yet been elucidated. Abnormal expression of genes and their polymorphisms play an important role in the pathogenesis of preeclampsia. DNA microarray technology, the use of DNA probe technology found some of the genes associated with preeclampsia, such as: human leukocyte antigen, endothelial nitric oxide synthase, vascular endothelial growth factor, angiotensin converting enzyme, vascular tension Suprasegic receptor II and other genetic variations and polymorphisms in patients with these genes, the incidence of preeclampsia significantly increased, changes in genes affect the corresponding system dysfunction, eventually leading to preeclampsia. With the development of molecular biology technology, it will surely find susceptible genes and make early screening and early diagnosis of preeclampsia possible.