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临床研究指出,用吡喹酮治疗感染度较重地区的血吸虫病患者的疗效逊于感染度较轻地区的。这一差异究竟是因药物对不同虫荷患者的疗效不同,抑或是由于在感染较重地区内受治患者易于重复感染,是值得探讨的一个问题。本文介绍吡喹酮治疗不同感染度的小鼠和家兔血吸虫病的结果,借作临床参考。 每兔感染50、200或500条日本血吸虫尾蚴的3组家兔,每组6～7只兔于感染8wk后用吡喹酮40mg/kg 1次灌胃治疗时,各组的减虫率依次分别为87.9,92.2和97.0％,明显高于感染4wk后用相同吡喹酮剂量治疗
Clinical studies have shown that the efficacy of praziquantel in the treatment of schistosomiasis in areas with more severe infections is less effective than in areas with less severe infections. Whether this difference is due to different efficacy of drugs in patients with different insects or because of repeated infections in treated patients in areas with severe infection is worth discussing. This article describes the results of praziquantel treatment of schistosomiasis in mice and rabbits at different levels of infection, for clinical reference. Rabbits infected with 50, 200 or 500 Schistosoma japonicum cercariae rabbits each group, each group of 6 to 7 rabbits infected with 8wk praziquantel 40mg / kg gavage treatment, the worm reduction rate of each group in turn Respectively 87.9, 92.2 and 97.0%, significantly higher than the same praziquantel dose after 4wk infection