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冷冻疗法曾试用于耳鼻喉科疾病的治疗,如血液病患者的扁桃体切除术、垂体切除术、鼻出血、美尼尔氏病、口腔溃疡、口腔角化症、青年性喉乳头状瘤及慢性鼻炎,亦用于良性、恶性肿瘤的治疗。其临床应用价值及适应症.至今尚未肯定。用冷冻破坏细胞主要根据细胞内冰晶形成及蛋白变性。结晶导致细胞脱水、胞膜破裂.使其中电解物浓度增加到毒害水平。小血管的血栓形成及局部缺血,将增加组织的破坏。此外,对冷冻组织可形成抗体,这种免疫反应可能有重要意义。破坏细胞的临界温度为-20℃,如温度改变速度保持恒定,温度再下降,并不增加细胞的坏
Cryotherapy has been used in the treatment of otolaryngology diseases such as tonsillectomy, pituitary resection, epistaxis, Meniere’s disease, oral ulcer, oral keratosis, laryngeal papilloma and chronic Rhinitis, also used for the treatment of benign and malignant tumors. Its clinical value and indications has not yet been confirmed. Cryogenic destruction of cells is mainly based on intracellular ice crystals and protein denaturation. Crystallization leads to cell dehydration, cell membrane rupture, where the concentration of electrolytes is increased to toxic levels. Small blood vessels thrombosis and ischemia, will increase tissue damage. In addition, antibodies can form on frozen tissue and this immune response may be of importance. The critical temperature for damaging the cells is -20 ° C, as the rate of temperature change remains constant and the temperature drops again without increasing the cell damage