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为了探索ｐ５３蛋白与肺癌的组织学类型、淋巴结转移等因素的关系。用免疫组织化学方法检测了５４例肺癌ｐ５３蛋白的表达。结果表明，阳性表达率为肺鳞癌２７．３％（６／２２），腺癌３６．８％（８／２０），腺鳞癌１００％（１／１），小细胞癌７５％（９／１２）。随着分化程度的不同表达率亦不同，高中低分化肺癌分别为３５．７％、４２．９％、４５．５％。淋巴结有无转移的患者ｐ５３蛋白表达率分别为４８．４％和３４．８％，各组之间的差异较显著。提示：ｐ５３蛋白表达可以反应肺癌细胞的活性，为研究肺癌的生物学行为提供了一个良好的标志物。
In order to explore the relationship between p53 protein and lung cancer histological type, lymph node metastasis and other factors. Immunohistochemistry was used to detect the expression of p53 protein in 54 cases of lung cancer. The results showed that the positive rate was 27.3% (6/22) in lung squamous cell carcinoma, 36.8% (8/20) in adenocarcinoma, 100% (1/1) in adenosquamous carcinoma, and 75% in small cell carcinoma (9 /12). With the different expression of different degrees of differentiation are also different, high-grade poorly differentiated lung cancer were 35.7%, 42.9%, 45.5%. The expression of p53 protein was 48.4% and 34.8% in patients with lymph node metastasis, respectively. The difference between the groups was significant. Tip: p53 protein expression can reflect the activity of lung cancer cells, providing a good marker for the study of the biological behavior of lung cancer.