为筛选分离对氰基苄氯和1-(4-氰基苄基)-1H-1,2,4-三氮唑较好的溶剂,采用静态平衡法测定了两种化合物在不同溶剂中的溶解度数据,为工业结晶分离工艺设计提供了基础数据。由分离系数的大小选出较好的溶剂,依次为乙酸乙酯、异丙醚和四氯化碳。采用λ-h方程对两种化合物在乙酸乙酯、异丙醚和四氯化碳溶剂中的溶解度数据进行了关联,计算值与实验值的平均相对偏差<5.6%,拟合效果良好。 In order to select and separate the better solvent of p-cyanobenzyl chloride and 1- (4-cyanobenzyl) -1H-1,2,4-triazole, the two compounds were determined by static equilibrium method in different solvents Solubility data for industrial crystallization separation process design provides the basic data. The better solvent was chosen from the size of separation factor, followed by ethyl acetate, isopropyl ether and carbon tetrachloride. The λ-h equation was used to correlate the solubility data of two compounds in ethyl acetate, isopropyl ether and carbon tetrachloride. The average relative deviation between calculated and experimental values ​​was <5.6%, and the fitting effect was good.