前报对微囊化阿司匹林制剂的生物利用度曾做过详细的研究和报道。结果表明,阿司匹林(Asp)粉包以乙基纤维素微囊膜,不仅可使它有缓释性能,并且能防止阿司匹林引起胃肠道组织出血。但是,当时在测定血药浓度时,以全部水杨酸(SA)作为标准,而且把家兔的给药量限制在600mg,在评价方法上不周之处很多。因此,作者试图进行更详细的实验。亦即将血浆中的水杨酸及其主要代谢物邻羟基马尿酸(Salicyluric acid, Previous reports on the bioavailability of microencapsulated aspirin formulations have been studied in detail and reported. The results showed that aspirin (Asp) powder coated with ethyl cellulose microcapsules, not only make it a sustained release performance, and can prevent gastrointestinal bleeding caused by aspirin. However, at that time, all the salicylic acid (SA) was used as a standard for the determination of the plasma concentration, and the amount of rabbit administered was limited to 600 mg, which was not satisfactory in the evaluation method. Therefore, the author tries to conduct more detailed experiments. Salicylic acid is also plasma and its main metabolite o-hydroxy hippuric acid (Salicyluric acid,