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[目的]了解高危型人乳头瘤病毒感染与宫颈病变的关系。[方法]对杭州市萧山区20～60岁常住妇女4446人进行妇科检查及宫颈HPV检测,并行宫颈细胞学检查,分析高危型人乳头瘤病毒感染与宫颈病变间相关性。[结果]HPV感染者462例,HPV总感染率为10.39%(462/4446),其中HR-HPV感染431例,HR-HPV感染率为9.69%(431/4446)。HR-HPV感染阳性者宫颈细胞学异常的检出率为40.13%(173/431);而HR-HPV阴性组中,宫颈细胞学异常的检出率为6.37%(256/4015),两者比较差异有统计学意义(χ2=508.443,P<0.001,OR=9.838,95%CI:7.813～12.388)。[结论]HR-HPV感染是宫颈病变的重要因素。
[Objective] To understand the relationship between high-risk human papillomavirus infection and cervical lesions. [Method] The gynecological examination and cervical HPV test were performed on 4446 women from 20 to 60 years old in Xiaoshan District of Hangzhou City. The cervical cytology was performed to analyze the correlation between high risk HPV infection and cervical lesions. [Results] Among the 462 HPV infected patients, the total HPV infection rate was 10.39% (462/4446), of which 431 were HR-HPV and the HR-HPV infection rate was 9.69% (431/4446). The positive rate of cervical cytology in HR-HPV infection was 40.13% (173/431), while in HR-HPV negative group, the detection rate of cervical cytology was 6.37% (256/4015) The difference was statistically significant (χ2 = 508.443, P <0.001, OR = 9.838, 95% CI: 7.813-12.388). [Conclusion] HR-HPV infection is an important factor of cervical lesions.