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多胺存在于所有生物细胞内,并随细胞增殖、分化而作相应的变化。大量研究表明,多胺通过直接与DNA相互作用、调节DNA构象和参与RNA及蛋白质的合成,而与细胞的增殖、分化密切相关,它是调节机体生理和病理过程中的重要因素之一。本文就多胺对细胞增殖的影响及其可能的机制进行综述。
Polyamines are present in all living cells and respond accordingly to cell proliferation and differentiation. Numerous studies have shown that polyamine directly regulates DNA conformation and participates in the synthesis of RNA and protein by interacting directly with DNA, which is closely related to the proliferation and differentiation of cells. It is one of the important factors in the regulation of physiological and pathological processes. This article summarizes the effects of polyamines on cell proliferation and their possible mechanisms.