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目的探讨小剂量阿司匹林联合乳果糖治疗轻微型肝性脑病的临床效果。方法 80例轻微型肝性脑病患者根据平行对照方法分为观察组(小剂量阿司匹林联合乳果糖治疗)与参考组(乳果酸治疗),各40例,观察两组患者临床治疗效果、血氨水平变化、不良反应发生情况。结果观察组治疗总有效率95.0%显著优于参考组70.0%(P<0.05);治疗后两组患者血氨水平均出现显著变化,组间差异具有统计学意义(P<0.05);观察组治疗期间不良反应发生率7.5%显著低于参考组30.0%(P<0.05)。结论小剂量阿司匹林联合乳果糖治疗轻微型肝性脑病效果显著,能够显著促进患者病情的改善,安全性较高。
Objective To investigate the clinical effect of low dose aspirin combined with lactulose on mild hepatic encephalopathy. Methods Eighty patients with mild hepatic encephalopathy were divided into observation group (low-dose aspirin combined with lactulose treatment) and reference group (lactate-induced acid therapy) according to the method of parallel control. The clinical efficacy, Changes in level, the occurrence of adverse reactions. Results The total effective rate of observation group was 95.0%, which was significantly better than that of reference group (70.0%, P <0.05). The levels of serum ammonia in both groups changed significantly after treatment, with statistical significance (P <0.05) The incidence of adverse reactions during the 7.5% was significantly lower than the reference group 30.0% (P <0.05). Conclusion Low-dose aspirin combined with lactulose treatment of mild hepatic encephalopathy significant effect, can significantly improve the patient’s condition and higher safety.