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[目的]观察血清抵抗素等因素在糖尿病组和健康对照组的组间差异及其与尿白蛋白排泄率的关系,以探讨抵抗素在糖尿病肾病发生发展中的作用,为临床上预防、治疗糖尿病肾病探索新的方法。[方法]选取住院的2型糖尿病患者56例,单纯2型糖尿病组18例;糖尿病肾病组38例,且其中伴有微量白蛋白尿(UAER20～200μg/min)组(G3)18例、临床糖尿病肾病(UAER﹥200μg/min)组20例;另选取糖耐量正常的健康对照组16例。分别测定血清抵抗素、糖化血红蛋白(HbAlC)、空腹血糖(FBG),并计算尿白蛋白排泄率(UAER),胰岛素抵抗指数(IRI),体重指数BMI等,观察以上指标在糖尿病组和健康对照组及血清抵抗素等因素的组间差异及其与尿白蛋白排泄率的关系。[结果]临床糖尿病肾病组血清抵抗素显著高于糖尿病微量白蛋白尿组、单纯2型糖尿病组和健康对照组,糖尿病微量白蛋白尿组血清抵抗素显著高于单纯2型糖尿病组和健康对照组。[结论]抵抗素在2型糖尿病及微量尿白蛋白的形成和发展中起着一定的作用。
[Objective] To observe the difference of serum resistin and other factors between diabetic group and healthy control group and its relationship with urinary albumin excretion rate to explore the role of resistin in the development of diabetic nephropathy for the prevention and treatment of clinical Diabetic nephropathy explore new ways. [Methods] Fifty-six inpatients with type 2 diabetes mellitus, 18 with type 2 diabetes mellitus and 38 with diabetic nephropathy were enrolled in this study. Eighteen patients with microalbuminuria (UAER20 ~ 200μg / min) group (G3) Diabetic nephropathy (UAER> 200μg / min) group of 20 cases; another normal glucose tolerance group of 16 healthy controls. The levels of serum resistin, HbAlc and FBG were measured and the urinary albumin excretion rate (UAER), insulin resistance index (IRI) and body mass index (BMI) were calculated. The above indexes were observed in diabetic patients and healthy controls Group and serum resistin and other urinary albumin excretion rate. [Results] Serum resistin in diabetic nephropathy group was significantly higher than that in diabetic microalbuminuria group, simple type 2 diabetic group and healthy control group. Serum resistin in diabetic microalbuminuria group was significantly higher than that in simple type 2 diabetic group and healthy control group group. [Conclusion] Resistin plays a role in the formation and development of type 2 diabetes and microalbuminuria.