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恶性肿瘤细胞的侵袭转移与肿瘤细胞及其基质诱导产生的基质金属蛋白酶(MMPs)的水平呈正相关.Ⅳ型胶原酶(包括MMR-2和MMP-9)与肿瘤转移的关系是金属蛋白酶研究的热点.研究证明,通过抑制肿瘤细胞的金属蛋白酶活性能抑制肿瘤细胞的侵袭与转移.胞内抗体(intracellular anti-body,intrabody)技术是指应用基因重组技术在非淋巴细胞内表达具有生物活性的抗体,从而特异性干扰或阻断某些生物大分子的活性或加工、分泌过程,引起细胞的一系列生物过程发生改变.它是新兴的基因治疗途径.研究证明,胞内抗体技术可以在分泌途径上、在细胞质或细胞核内阻断癌相关蛋白的活性.
The invasion and metastasis of malignant tumor cells is positively correlated with the level of matrix metalloproteinases (MMPs) induced by tumor cells and their matrix. The relationship between type IV collagenase (including MMR-2 and MMP-9) and tumor metastasis is the study of metalloproteinases. Hot spots. Studies have shown that inhibiting the invasion and metastasis of tumor cells by inhibiting the metalloproteinase activity of tumor cells. The intracellular anti-body (intrabody) technique refers to the use of gene recombination technology to express biological activity in non-lymphocytes. Antibodies, which specifically interfere with or block the activity or processing and secretion of certain biological macromolecules, cause a series of biological processes in the cell to change. It is an emerging gene therapy approach. Studies have shown that intracellular antibody technology can be secreted Blocking the activity of cancer-associated proteins in the cytoplasm or nucleus.