论文部分内容阅读
CD44(cluster of differentiation 44)指白细胞分化抗原簇第44号,是一类重要的黏附分子,广泛分布于细胞表面,如淋巴细胞、单核细胞、成纤维细胞、内皮细胞等[1]。不同细胞表面CD44与透明质酸(HA)结合活性不同,活化状态存在很大差异。许多正常细胞表面CD44处于相对静止状态,而许多肿瘤细胞表面CD44处于高度活化状态,能与其主要配体HA结合,参与肿瘤的发生、发展及转移等[2-6]。目前,有关CD44活化的调控机制仍未完全阐明,但随着对CD44研究的不断深
Cluster of differentiation 44 (CD44) is an important class of adhesion molecules that are widely distributed on the surface of cells such as lymphocytes, monocytes, fibroblasts, and endothelial cells [1]. Different cell surface CD44 and hyaluronic acid (HA) binding activity, the activation state there is a big difference. Many normal cells on the surface of CD44 in a relatively quiescent state, and many tumor cell surface CD44 is highly activated, with its main ligand HA binding, involved in tumorigenesis, development and metastasis [2-6]. At present, the regulatory mechanism of CD44 activation has not yet been fully elucidated, but as the study of CD44 continues to deepen