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心力衰竭是各种心血管疾病发展的终末阶段。室性心律失常是心力衰竭患者死亡的主要危险因素之一,发生率可达80%～95%。目前认为,心力衰竭时,诸多因素的影响导致心肌电生理异常,通过触发活动、自律性异常、折返激动等机制诱发心律失常。临床目前常用的四大类抗心律失常药物均疗效不佳,因此深入探讨心力衰竭并发室性心律失常的发生机制,寻找抗心律失常药物的新靶点,对于心力衰竭心律失常的治疗有重要意义。
Heart failure is the terminal stage of the development of various cardiovascular diseases. Ventricular arrhythmia is one of the major risk factors for death in patients with heart failure, the incidence of up to 80% to 95%. At present, the heart failure, many factors lead to myocardial electrophysiological abnormalities, through triggering activities, self-discipline, abnormalities, reentry and other mechanisms induced arrhythmia. The four main types of antiarrhythmic drugs commonly used in clinic are ineffective. Therefore, in-depth discussion of the pathogenesis of heart failure complicated by ventricular arrhythmias and the search for new targets of antiarrhythmic drugs are of great significance for the treatment of arrhythmia in heart failure .