论文部分内容阅读
目的： 分析西安地区食管癌的分离比、遗传度和病例亲属的标准化死亡比（ＳＭＲ）． 方法： 应用遗传流行病学和病例对照研究方法，调查分析了西安地区２１１例食管癌病例和１８３例对照的亲属中食管癌发病情况． 结果： 病例组Ⅰ， Ⅱ级亲属中食管癌的发病率（分别为２．９５％ ， ０．６４％ ）均高于对照组（０．３２％ ），分离比为０．００８２～０．０２９４，不符合单基因遗传规律，Ⅰ，Ⅱ级亲属加权平均遗传度为５０．０２％ ，其中８４例病例各级亲属ＳＭＲ均大于１． 结论： 食管癌的遗传背景是食管癌的发病因素之一，但不是主要因素．
Objective: To analyze the segregation ratio, heritability, and standardized death ratio (SMR) of esophageal cancer in Xi’an. Methods: Genetic epidemiology and case-control study were used to investigate the incidence of esophageal cancer in 211 esophageal cancer cases and 183 control relatives in Xi’an. Results: The incidence of esophageal cancer in the case group I and II relatives (2.95% and 0.64%, respectively) was higher than that in the control group (0.32%). The separation ratio was 0.0082 to 0.0294. , Not consistent with the genetic inheritance of single genes, the weighted mean heritability of family I and II relatives was 50.02%, of which 84 cases had relative SMR greater than 1. Conclusion: The genetic background of esophageal cancer is one of the factors of esophageal cancer, but it is not the main factor.