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平阳霉素(博来霉素A_5,PYM),是中国医学科学院抗菌素研究所于1969年从我国浙江省温州的平阳地区土壤中分离出平阳链霉菌,并从其产生的多种博来霉素组分中筛选出的单一组分A5,是一种具有抗癌作用的抗生素。PYM的作用机制为抑制癌细胞的DNA合成和切断DNA链。临床上因其抗肿瘤疗效确切,对骨髓和免疫的抑制作用小,与其他抗癌药物无交叉耐药性,并具显效快等特点而被广泛应用。主要用于治疗皮肤癌、头颈部
Pingyangmycin (bleomycin A_5, PYM), is the Institute of Chinese Academy of Medical Sciences Institute of antibiotics in 1969 from Pingyang, Zhejiang Province, China Pingyang soil isolated from Streptomyces pingyang, and from the production of a variety of bleomycin Components selected from a single component A5, is an anti-cancer effect of antibiotics. The mechanism of action of PYM is to inhibit the DNA synthesis of cancer cells and to cut the DNA chain. Clinically because of its exact effect of anti-cancer, the inhibition of bone marrow and immune function is small, no cross-resistance with other anti-cancer drugs, and with markedly fast and other characteristics have been widely used. Mainly used to treat skin cancer, head and neck