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目的了解深圳市男男性行为人群(MSM)的艾滋病病毒(HIV)/梅毒发病密度,探索防治性病对预防控制艾滋病的作用。方法知情同意原则下,招募符合纳入标准的MSM;建立并保持队列,收集社会人口学、性行为和安全套使用等资料;抽血检测HIV/梅毒,随访观察HIV/梅毒转归结局。结果 609例入选队列,HIV阴转阳19例,观察总人年数249.7人年,发病密度7.6[95%可信区间(CI):4.6～11.9]/100人年;梅毒酶联免疫吸附试验(ELISA)阴转阳18例,观察总人年数134.9人年,发病密度13.3(95%CI:7.9～21.1)/100人年;梅毒ELISA阳性队列HIV发病密度是梅毒ELISA阴性队列HIV发病密度的2.2倍。结论梅毒对HIV传播具有协同作用,有必要在该人群中实施有效的性病预防措施以控制HIV传播。
Objective To understand the incidence of HIV / syphilis in MSM in Shenzhen and to explore the role of prevention and treatment of STDs in the prevention and control of AIDS. Methods Informed consent was recruited to meet the inclusion criteria for MSM; establishment and maintenance of a cohort to collect data on socio-demography, sexual behavior and condom use; and blood / blood tests for HIV / syphilis were followed up to assess the outcome of HIV / syphilis. Results Sixty-nine patients were enrolled in the cohort and HIV-negative patients were positive in 19 cases. The total number of years was 249.7 years, with a disease-free density of 7.6 [95% confidence interval (CI): 4.6-11.9] / 100 years. Syphilis enzyme-linked immunosorbent assay ELISA) yielded positive results in 18 cases. The observed total number of years was 134.9 person-years, and the incidence density was 13.3 (95% CI: 7.9-21.1) per 100 person-years. The prevalence of HIV infection in syphilis ELISA positive cohorts was 2.2 Times Conclusion Syphilis has a synergistic effect on HIV transmission and it is necessary to implement effective STD prevention measures in this population to control HIV transmission.