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目的研究肺结核患者细胞因子的表达。方法收取2006年1月~2008年6月成年新发肺结核患者120例及健康成年人120例血标本,检测T淋巴细胞(CD3+)及T淋巴细胞亚群CD4+、CD8+及CD4+/CD8+比值及白细胞介素12(IL-12)含量,并进行分析。结果肺结核患者组CD3+、CD4+、IL—12含量呈不同程度减少,低于健康成人组。CD8+含量呈相对增多,CD4+/CD8+比值肺结核病人组下降。结论细胞因子含量与肺结核发病密切相关,监测人体细胞因子水平对掌握结核病病情发展有重要意义。
Objective To study the expression of cytokines in patients with pulmonary tuberculosis. Methods Blood samples were collected from 120 newly diagnosed pulmonary tuberculosis patients and 120 healthy adults from January 2006 to June 2008, and the ratios of CD4 +, CD8 + and CD4 + / CD8 + of T lymphocyte subsets and T lymphocyte subsets Interleukin 12 (IL-12) levels were determined and analyzed. Results The levels of CD3 +, CD4 + and IL-12 in patients with pulmonary tuberculosis decreased to different degrees, which were lower than those in healthy adults. CD8 + content was relatively increased, CD4 + / CD8 + ratio of patients with pulmonary tuberculosis decreased. Conclusions Cytokine levels are closely related to the pathogenesis of pulmonary tuberculosis. It is of great importance to monitor the level of human cytokines in order to grasp the progression of tuberculosis.