系统性硬皮病(SSc)是一影响结缔组织的自身免疫性疾病,其免疫功能异常的标志是血清抗核抗体(ANA)的出现,90％以上的SSc患者ANA阳性。本文通过回顾性研究观察各种ANA与临床特征以及预后的相关性。 275例患者来自1971～1990年日本Keio大学医学院的初诊患者,均符合美国风湿病学会关于SSc的诊断标准。观察2年,在初诊的第一年内采集每个患者的血清标本,检测8种与SSc相关的ANA。 Systemic scleroderma (SSc) is an autoimmune disease affecting connective tissue. The hallmarks of abnormal immune function are the presence of serum antinuclear antibodies (ANA), and more than 90% of patients with SSc have ANA positive. This article through a retrospective study observed a variety of ANA and clinical features and prognosis. A total of 275 patients were from newly diagnosed patients at Keio University School of Medicine in Japan from 1971 to 1990 and all met the American College of Rheumatology criteria for diagnosis of SSc. After 2 years of observation, serum samples from each patient were collected during the first year of the first visit, and eight SSCs-associated ANAs were detected.