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目的对头孢类抗菌药物联合其他药物致临床不良反应进行分析,探索联合用药的安全性和对策。方法对于2013年3月-2014年3月医院收治的300名患者作为研究对象,给予患者服用头孢类抗菌药物、喹诺酮类抗菌药物以及青霉素类抗菌药物的联合用药治疗,观察记录用药患者出现的临床不良反应,并统计分析联合用药诱发不良反应与患者的年龄、性别、过敏史以及临床护理等因素的相关性。结果 300例患者中有42例患者具有过敏史,其中具有青霉素过敏史患者28例,占研究对象9.3%;由于护理差错诱发的不良反应患者4例,占比1.3%。结论头孢类抗菌药物联合其他药物诱发患者出现不良反应的主要因素在于患者是否有过敏史,以及临床护理操作,与患者的年龄和性别无关。因此,临床护理过程中应强化护理人员的工作服务意义和职业技能,提高对患者过敏史的筛选,以此改善头孢类抗菌药物联合用药的安全性,降低联合用药出现的不良反应,改善患者的就医质量。
Objective To analyze the clinical adverse reactions of cephalosporin antibiotics combined with other drugs and explore the safety and countermeasures of combination therapy. Methods A total of 300 patients admitted from March 2013 to March 2014 in our hospital were enrolled in this study. Patients were treated with cefoperazone, quinolone antibiotics and penicillin antibiotics. The clinical records of patients Adverse reactions, and statistical analysis of the combination of drug-induced adverse reactions and patient age, gender, history of allergy and clinical nursing and other factors. Results Among the 300 patients, 42 patients had anaphylactic history. Among them, 28 patients had a history of penicillin allergy, accounting for 9.3% of the study subjects; 4 patients had adverse reactions due to nursing errors, accounting for 1.3%. Conclusion The main factors that cause adverse reactions in patients with cephalosporin antibiotics combined with other drugs are whether patients have allergies or not, and the clinical nursing operation has nothing to do with the patient’s age and gender. Therefore, the clinical nursing process should strengthen the nursing staff’s sense of service and occupational skills, improve the history of allergic patients screening, in order to improve the safety of cephalosporins antimicrobial agents combined to reduce the adverse reactions of combination therapy to improve the patient’s Medical quality.