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幽门螺杆菌(H.pylori)是一类基因组结构变异较大的细菌,除具有一般共同特征、看家基因、插入序列、致病岛和质粒外,还具有特殊的毒力基因。H.pylori基因组结构的不断阐明,为其临床和流行病学研究以及感染的预防和控制打下了坚实的基础。新发现的H.pylori致病因子,如jhp0917-0918、jhp0947和jhp0949基因均与胃十二指肠疾病相关,提示其可能成为H.pylori新的流行病学标志。
Helicobacter pylori (H. pylori) is a group of bacteria with large variation in genomic structure. In addition to common common features, housekeeping genes, insert sequences, pathogenic islands and plasmids, it also has a special virulence gene. The constant clarification of the H.pylori genome structure has laid a solid foundation for its clinical and epidemiological studies and for the prevention and control of infections. The newly discovered virulence factors of H.pylori, such as jhp0917-0918, jhp0947 and jhp0949, are all associated with gastroduodenal diseases, suggesting that they may become new epidemiological markers of H.pylori.