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AIM:To investigate the association between hypoxiainducible factor-1α(HIF-1α) polymorphisms(-1772C>T and-1790G>A) and the risk of digestive tract cancer.METHODS:A total of 13 eligible studies were retrieved from Pub Med,EMBASE,and the ChinaNational Knowledge Infrastructure database.The odds ratios(ORs) and 95% confidence intervals(CIs) were calculated to estimate the strength of the associations.RESULTS:By pooling the eligible studies,we found that the HIF-1α-1772C>T polymorphism was not associated with the risk of developing digestive tract cancer(dominant comparison,OR:1.156; 95%CI:0.839-1.593; P heterogeneity = 0.007),and no significant association was found in the Asian population or the Caucasian population.However,for the-1790G>A polymorphism,carriers of the variant-1790 A allele had a significantly increased risk of digestive tract cancer compared with those with the wildtype-1790 G allele(dominant comparison,OR:3.252; 95%CI:1.661-6.368; P heterogeneity < 0.001).Additionally,this increased risk of digestive cancer was only detected in Asians; there was no significant association in Caucasians.CONCLUSION:This meta-analysis demonstrates that the HIF-1α-1790G>A polymorphism is associated with a significantly increased risk of digestive tract cancer,while the-1772C>T polymorphism is not.
AIM: To investigate the association between hypoxiainducible factor-1alpha (HIF-1alpha) polymorphisms (-1772C> T and-1790G> A) and the risk of digestive tract cancer. METHODS: A total of 13 eligible studies were from Pub Med, EMBASE, and the ChinaNational Knowledge Infrastructure database. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the associations.RESULTS: By pooling the eligible studies, we found that the HIF-1α- 1772C > T polymorphism was not associated with the risk of developing digestive tract cancer (OR: 1.156; 95% CI: 0.839-1.593; P heterogeneity = 0.007), and no significant association was found in the Asian population or the Caucasian population . Still, for the-1790G> A polymorphism, carriers of the variant-1790 A allele had a significantly increased risk of digestive tract cancer compared with those with the wildtype-1790 G allele (dominant comparison, OR: 3.252; 95% CI: 1.661-6.368; P heterogeneity <0.001). Additionally, this increased risk of digestive cancer was only detected in Asians; there was no significant association in Caucasians. CONCLUSION: This meta-analysis demonstrates that the HIF-1α-1790G> A polymorphism is associated with a significantly increased risk of digestive tract cancer, while the-1772C> T polymorphism is not.