听神经听力丧失是线粒体疾病最常见的表型 ,到目前为止 ,在已报道家族性非综合征性母系遗传听力损伤的家庭中有 4种线粒体 DNA( mt DNA)点突变 ,最常见的是 1 2 Sr RNA基因 A1 5 5 5 G突变 ,可引起对氨基苷耳毒性副作用增加其敏感性。另外的 3种点突变是 A7445 G,7472 ins C,T7 Auditory nerve hearing loss is the most common phenotype of mitochondrial disease and to date, there have been four point mutations in mitochondrial DNA (mt DNA) in families that have reported familial non-syndromic maternal genetic hearing impairment, the most common being 12 The mutation of the A1 5 5 5 G of the Sr RNA gene can cause its side effects on aminoglycoside ototoxicity to increase its sensitivity. The other three point mutations are A7445 G, 7472 ins C, T7