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目的探讨宫颈环形电切术(LEEP)联合重组干扰素α-2b栓治疗宫颈高危型乳头瘤病毒(HPV)感染的疗效。方法选取妇产科门诊治疗宫颈高危型HPV感染患者70例,采用数字表将其随机分为观察组(n=35)和对照组(n=35)。两组患者均予以行LEEP术,观察组患者术毕立即阴道内放置重组干扰素α-2b栓,1枚/晚,连用14 d,下次月经后开始下一个疗程,连用3个疗程。对照组患者不予以重组干扰素α-2b栓治疗。观察并记录两组患者术后创面愈合时间、阴道流液时间及术后并发症,并比较治疗后6个月的临床效果。结果观察组患者术后创面愈合时间和阴道流液时间明显短于对照组(P<0.05)。观察组术后发生并发症2例,对照组术后发生并发症8例,观察组术后并发症的发生率(5.71%)明显低于对照组(22.86%)(χ2=4.20,P<0.05)。治疗后6个月,观察组患者临床总有效率(91.43%)明显高于对照组(71.43%)(χ2=6.47,P<0.05)。结论 LEEP联合重组干扰素α-2b栓治疗宫颈高危型HPV感染的疗效显著,有利于促进宫颈创面的愈合,缩短创面愈合时间及阴道流液时间,减少术后并发症发生,且其HPV清除率较高,能有效控制病情发展和HPV的复发。
Objective To investigate the efficacy of cervical ring electrosurgical excision (LEEP) combined with recombinant interferon α-2b suppositories for the treatment of cervical high-risk papillomavirus (HPV) infection. Methods Obstetrics and Gynecology outpatient treatment of 70 cases of high-risk cervical HPV infection were randomly divided into observation group (n = 35) and control group (n = 35). Two groups of patients were given LEEP surgery, the observation group patients immediately after surgery placed intravaginal recombinant interferon α-2b suppositories, 1 / night, once every 14 days, the next menstruation began the next course of treatment, once every 3 courses. Patients in the control group were not treated with recombinant interferon alpha-2b. The wound healing time, vaginal fluid time and postoperative complications of the two groups were observed and recorded. The clinical effect at 6 months after treatment was compared. Results The wound healing time and vaginal fluid time in the observation group were significantly shorter than those in the control group (P <0.05). There were 2 cases of postoperative complications in the observation group and 8 cases of postoperative complications in the control group. The incidence of postoperative complications in the observation group (5.71%) was significantly lower than that in the control group (22.86%) (χ2 = 4.20, P <0.05 ). At 6 months after treatment, the total effective rate (91.43%) in the observation group was significantly higher than that in the control group (71.43%) (χ2 = 6.47, P <0.05). Conclusion LEEP combined with recombinant interferon α-2b suppositories for the treatment of cervical high-risk HPV infection has a significant effect, which is beneficial to promote the healing of cervical wounds, shorten the wound healing time and vaginal fluid time and reduce postoperative complications, and the HPV clearance rate Higher, can effectively control the progression of the disease and HPV recurrence.