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目的:观察益气除痰法联合抗生素治疗晚期非小细胞肺癌合并肺部感染的临床疗效。方法:将132例患者随机分为益气除痰法组和对照组各66例,对照组在致病菌未查出前根据临床经验使用抗生素,然后根据药敏试验结果以及初步治疗反应选择最有效的抗生素足量应用;益气除痰法组在按照对照组使用抗生素的原则选用敏感抗生素治疗的基础上,加用以益气除痰法为主的中医药治疗,疗程为7～14天。结果:益气除痰法组总有效率为87.9%,对照组总有效率为72.7%,2组比较,差异有显著性意义(P<0.05)。抗生素使用时间益气除痰法组为(7.7±2.0)天,对照组为(8.9±2.1)天,2组比较,差异有非常显著性意义(P<0.001)。结论:根据益气除痰法辨证使用中医药联合抗生素治疗晚期非小细胞肺癌合并肺部感染的疗效优于单纯抗生素治疗。
Objective: To observe the clinical efficacy of Qi-benefiting and removing phlegm method combined with antibiotics in the treatment of advanced non-small cell lung cancer with pulmonary infection. Methods: 132 patients were randomly divided into Yiqiqitan group and control group of 66 cases, the control group in the pathogens were not detected before the use of antibiotics based on clinical experience, and then based on susceptibility test results and the initial choice of treatment response Effective antibiotics adequate application; Qi qi and removing sputum method in accordance with the principle of using antibiotics in the control group on the basis of the selection of sensitive antibiotics, plus the use of Qi in addition to phlegm-based Chinese medicine treatment, treatment for 7 to 14 days . Results: The total effective rate was 87.9% in the Qi-removing and eliminating-phlegm method group and 72.7% in the control group. There was significant difference between the two groups (P <0.05). The time of using antibiotics was (7.7 ± 2.0) days in the Yiqiqitan group and (8.9 ± 2.1) days in the control group. There was significant difference between the two groups (P <0.001). Conclusion: According to the method of supplementing qi and removing phlegm, it is better than the antibiotic therapy to treat the patients with advanced non-small cell lung cancer complicated with pulmonary infection by TCM combined with antibiotics.