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高强度聚焦超声作为一种非侵入性、无毒副作用的肿瘤治疗手段,目前已应用于乳腺癌、子宫肌瘤等的临床治疗。但对无创经颅高强度聚焦超声脑肿瘤治疗而言,由于颅骨的非均质结构及其声学特性导致经颅超声的相位和幅值失真,引发颅内散焦、焦点偏移和颅骨周围正常组织损伤等临床问题的发生。近年来随着经颅超声相控换能器及其控制技术的发展,高强度聚焦超声经颅脑肿瘤治疗成为可能。本文就近年来经颅脑肿瘤HIFU治疗的相关技术进行综述。
High-intensity focused ultrasound as a non-invasive, non-toxic side effects of cancer treatment, has been used in breast cancer, uterine fibroids and other clinical treatment. However, non-invasive transcranial high-intensity focused ultrasound brain tumor treatment, due to the heterogeneous structure of the skull and its acoustic properties lead to transcranial ultrasound phase and amplitude distortion, causing intracranial defocus, focal shift and normal skull Tissue damage and other clinical problems. In recent years, with the development of transcranial ultrasound phase-controlled transducer and its control technology, it is possible to treat high-intensity focused ultrasound by brain tumor. This article reviews the related technologies of HIFU treatment in brain tumors in recent years.