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目的观察不同治疗方法对不同分期的颊黏膜鳞状细胞癌的临床疗效。方法对2003-01/2013-12月作者医院收治的80例颊黏膜鳞状细胞癌患者采取不同的治疗方法,其中单纯手术治疗16例,单纯放疗9例,单纯化疗1例,综合治疗(手术+放疗或手术+放疗+化疗或放疗+化疗)54例。结果 5年生存率分别是Ⅰ期60%,Ⅱ期48.28%,Ⅲ期30.30%,Ⅳ期0。局部复发是颊黏膜鳞状细胞癌治疗失败的最主要原因。单纯放射治疗原发灶总剂量70Gy。术后瘤床预防照射剂量60Gy,对术后有残留或切缘阳性者70Gy。结论对于Ⅰ期病例单纯手术或单纯放射治疗取得较高的生存率,Ⅱ、Ⅲ期病例应采用综合治疗,Ⅳ期病例治疗效果不理想。术后放射治疗可以提高颊黏膜鳞状细胞癌的局控率和生存率。
Objective To observe the clinical effects of different treatment methods on different stages of buccal mucosal squamous cell carcinoma. Methods Eighty patients with squamous cell carcinoma of the buccal mucosa treated in the author hospital from January 2003 to December 2013 were treated with different methods, of which 16 were treated by simple operation, 9 were treated by radiotherapy alone, and 1 was treated by chemotherapy alone + Radiotherapy or surgery + radiotherapy + chemotherapy or radiotherapy + chemotherapy) 54 cases. Results The 5-year survival rates were 60% in stage Ⅰ, 48.28% in stage Ⅱ, 30.30% in stage Ⅲ, and 0 in stage Ⅳ. Local recurrence is the most important reason for the failure of treatment of buccal squamous cell carcinoma. Simple radiotherapy primary tumor total dose 70Gy. Postoperative tumor bed irradiation dose of 60Gy, residual or positive margins 70Gy. Conclusions For stage Ⅰ cases, simple surgery or radiotherapy alone has a higher survival rate. Patients in stage Ⅱ and Ⅲ should be treated with comprehensive therapy, and stage Ⅳ should not be treated with satisfactory results. Postoperative radiotherapy can improve the control rate and survival rate of buccal mucosal squamous cell carcinoma.