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多肽、蛋白类药物因其特有的疗效,近20年来受到越来越广泛的关注。但因其不稳定性、半衰期短等缺点,难以直接应用。脂质体作为该类药物的载体,有着特别的意义。1脂质体1.1脂质体的组成和基本特性脂质体(liposomes)是由磷脂和/或胆固醇及其它两亲性物质分散于水中,组成脂质双分子膜,再由双分子膜形成一层或多层空心的球状体或类球状体。脂质体是类似于生物膜结构的囊泡。脂质体有单室与多室之分。小单室脂质体(SUV)的粒径在20～80nm之间,也称为纳米脂质体,大单室脂质体(LUV)的粒径在0.1～1μm之间,多室脂质体(MLV)的粒径在1～5μm之间。最近有人研制了粒径为5
Peptides and protein drugs have drawn more and more attention in recent 20 years because of their unique curative effect. But because of its instability, short half-life and other shortcomings, it is difficult to direct application. Liposomes as a carrier of such drugs, has a special significance. 1 liposomes 1.1 the composition of liposomes and the basic characteristics of the liposomes (liposomes) is the phospholipids and / or cholesterol and other amphipathic substances dispersed in water to form a lipid bilayer membrane, bilayer membrane from the formation of a Layer or layers of hollow spheroids or spheroids. Liposomes are vesicles that resemble biofilm structures. Liposomes have more than one room and multi-chamber. Small single-compartment liposomes (SUV) particle size between 20 ~ 80nm, also known as nano-liposomes, large chamber liposomes (LUV) particle size between 0.1 ~ 1μm, multi-compartment lipid Body (MLV) particle size between 1 ~ 5μm. Recently someone developed a particle size of 5