阿托品是抢救有机磷中毒的特效药物之一,如何合理地应用,是抢救成败的关键。本文就此结合文献作一综述。一、根据病情尽早给药有机磷中毒病势凶猛,发展迅速,尤以呼吸道中毒,数分钟内便可致死。引起死亡的原因有:①呼吸中枢抑制;②支气管痉挛合并呼吸道分泌物过多;③血管扩张,血压下降,导致循环障碍;④膈肌和肋间肌接头麻痹;⑤中枢性剧烈惊厥,加剧气体交换功能障碍。早期足量给予阿托品可有效地对抗呼吸中枢抑制,支气管痉挛合并呼吸道分泌物过多和循环衰竭。对中枢性惊厥也有一定作用,故给药愈早,效果越 Atropine is the rescue of organophosphate poisoning one of the effects of drugs, how to rational use, is the key to the success or failure of the rescue. This article is a summary of the literature. First, according to the disease as soon as possible organophosphate poisoning fierce situation, the rapid development, especially respiratory poisoning, can be fatal within minutes. Causes of death are: ① respiratory depression; ② bronchial spasm with respiratory secretions; ③ vasodilation, blood pressure, leading to circulatory disorders; ④ diaphragm and intercostal muscle paralysis; ⑤ central severe seizures, exacerbating the gas exchange disfunction. Early adequate administration of atropine can effectively counter respiratory depression, bronchospasm with respiratory secretions and circulatory failure. Central convulsions also have a role, so the sooner the drug, the effect of the more