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[目的]分析饮食干预对抗结核药物吡嗪酰胺引起血尿酸水平升高而导致停药的影响及意义。[方法]采用对照研究，将服用吡嗪酰胺等引起血尿酸增高的结核患者分为两组，2007～2008年112名于本院结核门诊经治的患者作为干预组，2006至2007年110名于长宁区疾病控制中心结防科经治的患者作为对照组。干预组在抗痨治疗的同时单纯给予饮食干预，不加用其他控制血尿酸的药物，饮食干预得到家属的有效配合，主要措施是多饮水、保暖以及碱化尿液等，对照组无饮食要求，观察比较两组患者血尿酸水平变化及停药率。[结果]在化疗过程中干预组停药率为6．25％（7/112），明显低于对照组停药率76．36％（84/110），且两组比较差异有显著性（ P ＜0．05）；干预组治疗1个月末时血尿酸升高值比对照组平均下降了7％；治疗2个月末时血尿酸升高值平均下降了10％以上。[结论]饮食干预可有效控制吡嗪酰胺引起的血尿酸升高水平，并大大降低化疗过程中的停药率，具有良好的临床意义。“,”[Objective] To analyze the effect of diet intervention on the increased uric acid level in serum leading to withdrawal caused by anti-tuberculosis drug pyrazinamide and its significance .[Methods]The control study was used .The tuberculosis patients with the increased uric acid level in serum caused by pyrazinamide were divided into two groups .To-tally 112 outpatients in the tuberculosis department of our hospital from 2007 to 2008 were taken as intervention group , while 110 patients treated in tuberculosis prevention and control department of the center for disease control in Changning district from 2006 to 2007 were taken as control group .The intervention group received anti-tuberculosis treatment and simple diet intervention without other medicines to control serum urinary acid .Family members sustained the work of diet intervention effectively .The main methods of diet intervention included drinking more water ,keeping warm and alkalizing urine ,etc .The control group needed no dietary requirements .The change of serum uric acid level and withdrawal rate in two groups were observed and compared .[Results] The withdrawal rate in intervention group during chemotherapy process was 6 .25% (7/112) which was obviously lower than that in control group (76 .36% ,84/110) ,and there was sig-nificant difference between two groups ( P<0 .05) .Compared with control groups ,the increased uric acid value in inter-vention group at the end of treatment after one month and two months deceased by 7% and above 10% ,respectively .[Conclusion]Diet intervention can effectively control the increased uric acid level in serum caused by pyrazinamide and largely reduce the withdrawal in chemotherapy process .Therefore ,it has good clinical significance .