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目的探讨人类免疫缺陷病毒(HIV)阳性女性患者宫颈高危型人乳头病毒(HR-HPV)感染情况以及子宫颈细胞学筛查情况。方法选取2013年1月—2016年9月深圳市第三人民医院爱心门诊就诊的HIV阳性女性患者206例为观察组,另选同期妇科门诊行宫颈癌筛查的HIV阴性患者206例为对照组,对两组患者行宫颈HPV检测及子宫颈液基薄层细胞涂片检查(LCT),观察两组患者宫颈HR-HP感染情况及LCT异常情况,并对观察组患者免疫功能指标予以分析。结果观察组患者HR-HPV感染率为33.50%,同对照组16.50%对比,差异有统计学意义(P<0.05);观察组患者LCT阳性率为87.86%,同对照组49.51%比较,差异有统计学意义(P<0.05);观察组中,HR-HPV感染患者CD8~+细胞数与未感染者比较差异无统计学意义(P>0.05),CD4~+细胞数及CD4~+/CD8~+较未感染患者低,差异有统计学意义(P<0.05)。结论 HIV阳性女性HR-HPV感染概率较大,LCT阳性检出率更高,宫颈上皮病变及恶性病变发生风险较大;HIV阳性患者感染HR-HPV同CD4~+细胞数及CD4~+/CD8~+有一定关联。
Objective To investigate the prevalence of cervical high-risk human papillomavirus (HPV) infection in human immunodeficiency virus (HIV) positive women and screening of cervical cytology. Methods A total of 206 HIV positive women were selected as the observation group from January 2013 to September 2016 in Shenzhen Care People’s Hospital Outpatient Clinic. Another 206 patients with HIV-negative cervical cancer screening in the same gynecological clinic were selected as the control group The cervical HPV test and LCT were performed on both groups. The cervical HR-HP infection and LCT abnormalities in both groups were observed. The immune function of the observation group was analyzed. Results The infection rate of HR-HPV in the observation group was 33.50%, which was significantly different from that in the control group (16.50%) (P <0.05). The positive rate of LCT in the observation group was 87.86%, compared with 49.51% in the control group (P <0.05). There was no significant difference in the number of CD8 ~ + cells and the number of CD4 ~ + / CD8 in HR-HPV infected patients ~ + Were lower than those without infection, the difference was statistically significant (P <0.05). Conclusion The positive rate of HR-HPV infection in HIV-positive women is higher, the positive rate of LCT is higher, and the risk of cervical epithelial lesions and malignant lesions is higher. The positive rates of HR-HPV in HIV-positive women are similar to those of CD4 ~ + cells and CD4 ~ + / CD8 ~ + There is a certain correlation.