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目的探讨检测2型糖尿病(T2DM)合并高血压(HT)患者外周血中抵抗素的意义。方法选择2006年3月至2007年12月内分泌科与心脏科住院患者为研究对象,并设对照组。入选患者分为4组:单纯T2DM(A组,28例),T2DM合并HT组(B组,26例),单纯HT组(C组,30例),健康对照组(对照组,25例)。分别检测4组的空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)以及抵抗素水平,同时应用颈动脉超声测量颈内/外动脉的最大内中膜厚度(IMT),并探讨它们之间的关系。结果HT合并T2DM组患者外周血抵抗素水平明显高于其他3组〔(39.0±16.4)ng/ml vs(14.5±8.8)ng/ml、(14.3±5.6)ng/ml、(10.3±3.3)ng/ml,P均<0.05〕,对该组进行以血糖为因变量的多元回归分析发现,血糖的变化与年龄、BMI、舒张压和收缩压及血清抵抗素水平有关,进行年龄、BMI和血压调整后,血糖水平仍然与外周血抵抗素水平有关。结论外周血抵抗素水平是HT合并T2DM的独立危险因子。
Objective To investigate the significance of resistin in peripheral blood of patients with type 2 diabetes mellitus (T2DM) complicated with hypertension (HT). Methods From March 2006 to December 2007, endocrinology and cardiology inpatients were selected as research objects and a control group was established. The patients were divided into 4 groups: T2DM alone (group A, 28 cases), T2DM combined with HT group (group B, 26 cases), HT alone group (group C 30 cases), healthy control group (control group 25 cases) . The levels of fasting blood glucose (FBG), HbA1c, TC, TG, HDL-C and resistin in the four groups were measured respectively. Carotid artery ultrasound The maximum intima-media thickness (IMT) of the internal and external carotid arteries was measured and the relationship between them was explored. Results The levels of resistin in HT patients with T2DM were significantly higher than those in the other three groups (39.0 ± 16.4 ng / ml vs 14.5 ± 8.8 ng / ml vs 10.3 ± 3.3 ng / ml vs 14.3 ± 5.6 ng / ml vs ng / ml, P <0.05, respectively). Multiple regression analysis of blood glucose as dependent variable showed that the changes of blood glucose were related to age, BMI, diastolic and systolic blood pressure and serum resistin level. After adjusting for blood pressure, blood glucose levels are still related to peripheral blood resistin levels. Conclusion Peripheral blood resistin levels are independent risk factors for HT combined with T2DM.