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本文合成了6个1-取代-3-甲基芬太尼衍生物。初步的药理实验结果表明,它们均具有典型的吗啡样作用。某些1位β-取代乙烯基乙基衍生物有强镇痛活性。简要地讨论了其结构—活性关系。
Six 1-substituted-3-methylfentanyl derivatives were synthesized in this paper. Preliminary pharmacological experiments show that they all have a typical morphine-like effect. Certain 1-position β-substituted vinyl ethyl derivatives have potent analgesic activity. A brief discussion of its structure-activity relationship.