节律性化疗以低剂量、高频次给药为特点在肿瘤治疗中的应用日益广泛。其中环磷酰胺作为一种烷化剂,是最早应用于节律性化疗的细胞毒药物之一,在肿瘤节律性化疗中得到广泛的应用。本文对环磷酰胺节律性化疗抗肿瘤作用的机制、临床应用、方法优势以及目前存在的问题等研究进展进行了综述。最后强调了环磷酰胺节律性化疗在临床应用中的重要地位。环磷酰胺节律性化疗仍存在着许多的问题,需要通过更深入的研究去解决。 Rhythmic chemotherapy is characterized by low doses and high frequency of administration, which are widely used in cancer therapy. Among them, cyclophosphamide is one of the earliest cytotoxic drugs used in rhythmic chemotherapy as an alkylating agent and has been widely used in rhythmic chemotherapy of tumors. This review summarizes the research progress of anti-tumor mechanism, clinical application, method advantages and existing problems of cyclophosphamide rhythmic chemotherapy. Finally, the importance of cyclophosphamide rhythmic chemotherapy in clinical application is emphasized. Cyclophosphamide rhythmic chemotherapy is still there are many problems that need to be resolved through more in-depth research.