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呋喃嘧酮(M-170)是一个新发现的正在临床研究中的抗丝虫病新药。前曾合成~(14)C-呋喃嘧酮(Ⅰ)和~3H-呋喃嘧酮(Ⅱ)供研究其在动物体内的吸收、分布、排泄用。经~(14)C-呋喃嘧酮的示踪试验结果表明:该药口服后吸收快、排泄迅速,无明显积累,部分在体内代谢。
Furosemide (M-170) is a newly discovered new drug against filariasis in clinical studies. ~ (14) C-furopyrin (Ⅰ) and ~ 3H-furopyrin (Ⅱ) were synthesized before the study was used to study their absorption, distribution and excretion in animals. The results of the tracer test of ~ (14) C-furopyrin showed that the drug absorbed rapidly and excreted rapidly after oral administration without obvious accumulation and partly metabolized in vivo.