钩端螺旋体(以下简称为钩体)病是一种发病急、病情重、如不及时治疗死亡率颇高的疾病。自从发现青霉素有治疗钩体病作用以来,加之早期确诊率的提高,其病死数大为减低。但对大批人群暴发发病,青霉素则有药源受限、时常发生过敏反应且多次注射治疗不便等缺点。因而,寻找新的有效 Leptospira (hereinafter referred to as the leptospirosis) disease is an acute onset, severe illness, if not treated in time the high mortality rate of the disease. Ever since the discovery of penicillin for the treatment of leptospirosis, combined with an increased rate of early diagnosis, the number of deaths has been greatly reduced. However, the outbreak of a large number of people, penicillin has limited sources of drugs, frequent allergic reactions and multiple injections inconvenience shortcomings. Therefore, looking for new and effective