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儿童自体骨髓移植(ABMT)前大剂量化疗、放疗等部可能产生远期后遗症。为确定儿童ABMT后远期临床及功能性肺异常的发生率,对一组未经全身照身射(TBI)的病例进行了研究。 38例患不同实体瘤(37例)及急性淋巴细胞白血病(1例)患儿,ABMT后已存活3～11.5年(平均7年),移值时平均年龄6.9岁。预处理方案包括:含卡氮芥(BCNU)方案24例,含白消安方案9例,单用左旋苯丙氨酸氮芥5例。所有患儿均经全面肺部体查及胸部X线检查,33例还进行了肺功能试验(PFT)检查。 结果 32例PFT结果可供评价,15例(47％)PFT异常,17例正常。15例PFT异常患儿均未发现有阻塞性肺病,10例有肺限制性综合征,另5例未达列诊断标准。4例主诉有轻度运动性呼吸困难,6例有胸部X线
Pediatric autologous bone marrow transplantation (ABMT) before high-dose chemotherapy, radiotherapy and other ministries may have long-term consequences. To determine the incidence of long-term clinical and functional lung abnormalities after ABMT in children, a group of patients without a total body irradiation (TBI) were studied. Thirty-eight children with different solid tumors (n = 37) and acute lymphoblastic leukemia (n = 1) survived 3 to 11.5 years (mean 7 years) after ABMT, with a mean age of 6.9 years on shift. Pretreatment programs include: Carbunone (BCNU) program in 24 cases, 9 cases of busulfan-containing, monosyphosin nitrogen mustard in 5 cases. All children underwent comprehensive pulmonary examination and chest X-ray examination, and 33 patients underwent pulmonary function test (PFT). Results 32 cases of PFT were available for evaluation, 15 cases (47%) had abnormal PFT and 17 cases were normal. Fifteen children with PFT abnormalities did not find obstructive pulmonary disease, 10 patients had pulmonary restrictive syndrome, and the other 5 patients did not meet the diagnostic criteria. 4 cases complained of mild exercise dyspnea, 6 cases of chest X-ray