目的:探讨抑乳调经颗粒对卵巢摘除大鼠雌激素活性的影响。方法:采用卵巢摘除方法来制作大鼠卵巢早衰模型,观察抑乳调经颗粒对卵巢摘除大鼠子宫、脾、肾上腺脏器指数及血清E2、LH、FSH含量的影响。结果:抑乳调经颗粒可增加卵巢摘除大鼠子宫和肾上腺的脏器指数,防止子宫和肾上腺的萎缩;使卵巢摘除大鼠阴道角化上皮细胞增多,增强雌激素活性,提高血中E2水平。结论:抑乳调经颗粒对卵巢摘除大鼠具有促进雌激素分泌和抗卵巢早衰的作用。 Objective: To investigate the effect of Yankan Tiaojing granules on estrogen activity in ovariectomized rats. Methods: The model of ovarian premature ovarian failure was made by ovariectomy. The effect of YRTMT on the indexes of uterus, spleen and adrenal gland, serum E2, LH and FSH in ovariectomized rats was observed. Results: YMTJ can increase the organ index of uterus and adrenal in ovariectomized rats to prevent atrophy of the uterus and adrenal glands; increase the vaginal keratinocytes in ovariectomized rats, increase the activity of estrogen and increase the level of E2 in the blood. Conclusion: YMTJP can promote estrogen secretion and anti-ovarian premature aging in ovariectomized rats.