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甲磺酸帕珠沙星是第三代喹诺酮类抗菌药物,抗菌谱广。对革兰阴性菌抗菌活性与其他喹诺酮类相当,对革兰阳性菌的活性明显增强,尤其对厌氧菌有较强的作用,且抗生素后效应时间长。临床用于敏感菌所致呼吸道感染、泌尿道感染,妇科、外科、耳鼻喉科和皮肤科等感染性疾病。但在临床应用中甲磺酸帕珠沙星注射液可引起消化系统、神经系统、血液系统、心血管系统、泌尿系统不良反应,其中以消化系统、神经系统不良反应和静脉炎最常见,且高剂量组不良反应综合发生率高于低剂量组。为了减少药物的不良反应,提高药物的疗效,近年来广大药学工作者进行了扩大该药应用范围的研究。
Pazufloxacin mesylate is the third generation quinolone antibacterial drugs, antibacterial spectrum. Gram-negative bacteria antibacterial activity and other quinolones comparable to the activity of Gram-positive bacteria was significantly enhanced, especially for anaerobic bacteria have a strong role, and antibiotic effect after a long time. Clinically used for respiratory infections caused by sensitive bacteria, urinary tract infections, gynecology, surgery, otolaryngology and dermatology and other infectious diseases. However, pazufloxacin mesylate injection can cause adverse reactions in digestive system, nervous system, hematological system, cardiovascular system and urinary system in clinical application. Digestive system, adverse reaction of nervous system and phlebitis are the most common ones. The incidence of adverse reactions in high-dose group was higher than that in low-dose group. In order to reduce adverse drug reactions and improve the efficacy of drugs, in recent years, the majority of pharmaceutical workers to expand the scope of application of the drug.