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在裸鼠腹腔内人结直癌移植腐模型上观察了腹腔化疗(intraperitonealchemotherapyIPC)抗癌疗效对36例中晚期结直肠癌患者手术后早期施行大剂量大容积5-FuIPC。结果表明:IPC能有效的防治裸鼠腹腔内人结肠癌移植瘤的生长扩散,临床应用简便易行.安全,无严重毒副作用和并发症,近期疗效满意.IPC是防治中晚期结直肠癌术后腹腔复发和肝转移一种颇有前途的辅助化疗措施。
The intraperitoneal chemotherapy (intraperitoneal chemotherapy) IPC antitumor effect was observed in nude mice with intra-abdominal human cancer. The 36 patients with advanced colorectal cancer were given large doses of 5-FuIPC after surgery. The results showed that IPC can effectively prevent and treat the growth and spread of human colon cancer transplanted in nude mice. The clinical application is simple and easy. Safety, no serious side effects and complications, satisfactory results in the near future. IPC is a promising adjuvant chemotherapy to prevent and treat intraperitoneal recurrence and liver metastasis in patients with advanced colorectal cancer.