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本文报告使用一种长效磺胺制剂——磺胺6甲氧嘧啶,对245例脑膜炎球菌感染的患者进行了临床效果的研究。其中172例为脑膜炎伴有脑膜炎球菌菌血症,61例为脑膜炎,12例为脑膜炎球菌菌血症。其中43例为极重型,143例为重型,59例为中等型。磺胺6甲氧嘧啶的剂量:成人第一天给2次,每次2克,以后每天一次2克。小儿第一天按60～80毫克/公斤体重,以后每天按30～40毫克/公斤体重给药。上述方案治疗时,服药24小时后血内药物浓度平均为49微克/毫升:脑脊液内浓度,服药4小时后为25微克/毫升,24小时后为8微克/毫升。 149例应用磺胺6甲氧嘧啶,96例用大剂量青霉素5～8天治疗(对照组)。将病例分为三组:第一
This article reports the use of a long-acting sulfonamide formulation - sulfamethoxine, in 245 patients with meningococcal infection in clinical studies. Among them, 172 cases were meningitis with meningococcal bacteremia, 61 cases were meningitis and 12 cases were meningococcal bacteremia. Of these, 43 were extremely heavy, 143 were heavy and 59 were moderate. Sulfonamido 6 methoxypyrimidine dose: adult first day to 2 times, each 2 grams, once a day after 2 grams. The first day of children by 60 to 80 mg / kg body weight, after 30 ~ 40 mg / kg body weight daily. In the above-mentioned regimen, the intra-arterial drug concentration was 49 μg / ml on average after 24 hours of administration: the concentration in the cerebrospinal fluid was 25 μg / ml after 4 hours and 8 μg / ml after 24 hours. 149 cases of sulfonamides 6 methoxypyrimidine, 96 cases with high doses of penicillin 5 to 8 days treatment (control group). Divide the cases into three groups: first