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锌转运体8(ZnT8)是新近发现的特异性高表达于胰岛的锌转运体,主要功能是参与锌在细胞内的区室化以及锌的外排,从而降低胞质内锌的浓度。同时,SLC30A8多态性影响2型糖尿病的易患性,与2型糖尿病的发病机制有关。虽然ZnT8全身剔除的小鼠空腹及葡萄糖刺激后胰岛素均减少,但血糖浓度无明显改变,表明了ZnT8的缺乏影响胰岛功能,而对全身血糖代谢的影响比较局限。
Zinc transporter 8 (ZnT8) is a recently discovered zinc transporter with high expression in islets. Its main function is to participate in the compartmentalization of zinc in the cells and the efflux of zinc, thus reducing the concentration of zinc in the cytoplasm. Meanwhile, SLC30A8 polymorphism affects the susceptibility of type 2 diabetes, which is related to the pathogenesis of type 2 diabetes. Although the whole body of ZnT8-depleted mice showed a decrease in fasting and glucose-stimulated insulin, there was no significant change in blood glucose concentration, indicating that the lack of ZnT8 affects islet function and has a limited effect on systemic blood glucose metabolism.