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目的探讨阿托伐他汀钙片联合胺碘酮治疗慢性心力衰竭(CHF)并室性心律失常的疗效。方法将81例CHF并室性心律失常患者分成两组,均给予常规治疗,对照组加用胺碘酮,观察组加用阿托伐他汀钙片和胺碘酮,观察两组的疗效、心电图和心功能变化,以及部分细胞因子水平。结果观察组疗效明显,总有效率与对照组比较差异有统计学意义(P<0.05)。观察组LVEF、6MWT均明显高于对照组,差异有统计学意义(P<0.05)。观察组BNP、Hs-CRP水平明显低于对照组,两组比较差异均有统计学意义(P<0.05)。无明显不良反应。结论阿托伐他汀钙片联合胺碘酮对CHF并室性心律失常患者的临床疗效较好,且安全性高。
Objective To investigate the curative effect of atorvastatin combined with amiodarone on ventricular arrhythmia in patients with chronic heart failure (CHF). Methods Eighty-one patients with CHF and ventricular arrhythmia were divided into two groups. All patients were given conventional therapy. Amiodarone was added to the control group. Atorvastatin calcium tablets and amiodarone were given to the observation group. The curative effect and electrocardiogram And heart function changes, as well as some cytokine levels. Results The observation group had obvious curative effect and the total effective rate was significantly different from the control group (P <0.05). The LVEF and 6MWT in the observation group were significantly higher than those in the control group (P <0.05). The levels of BNP and Hs-CRP in the observation group were significantly lower than those in the control group, with significant difference between the two groups (P <0.05). No obvious adverse reactions. Conclusions Atorvastatin combined with amiodarone has good clinical efficacy and safety in patients with CHF and ventricular arrhythmia.