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目的:利用波速形成算法研究大鼠海马中theta波的传播规律。方法 :探讨了自适应波速形成算法在大鼠场电位中的应用。选取了5只大鼠,在大鼠的海马中植入8×2阵列的微丝电极阵列,训练大鼠做静止、跑动、攀爬等动作,利用视屏跟踪系统监视大鼠活动,神经信号记录仪记录大鼠的海马神经元放电和场电位,利用自适应波束形成算法分析theta波对记录电极的到达角。结果:在大鼠静止时无theta波,运动时存在明显的theta波,其传播角度保持稳定。本研究确认了theta波在海马中以行波的方式传播,传播的角度可以通过波束形成算法计算。结论:通过应用在雷达和声纳技术广泛使用的波束形成算法,能够简便的计算theta波相对于电极阵列的到达角,可能为手术电极定位提供辅助。
OBJECTIVE: To study the propagation of theta waves in the hippocampus of rats using wave velocity formation algorithm. Methods: The application of adaptive wave speed formation algorithm in rat field potentials was discussed. Five rats were selected, 8 × 2 arrays of micro-wire electrode arrays were implanted into the hippocampus of rats to train the rats to do the activities such as rest, running and climbing, and to monitor the activities of the rats by using the video-screen tracking system. The neural signals The recorder recorded the rat hippocampal neuron discharge and field potential, and analyzed the angle of arrival of theta wave to the recording electrode by adaptive beamforming algorithm. Results: There was no theta wave when the rats were at rest, and there was obvious theta wave during the exercise. The propagation angle remained stable. This study confirms that theta waves propagate in the hippocampus by traveling waves, and the propagation angle can be calculated by the beamforming algorithm. Conclusion: By using beamforming algorithms widely used in radar and sonar technology, the arrival angle of theta wave with respect to the electrode array can be calculated easily, which may provide assistance for positioning the surgical electrodes.